Abstract

VELASQUEZ, Camilo A.; GONZALEZ, Miguel; BERROUET, Marie C.  and  JARAMILLO, Nicolás. Chemotherapy-induced cardiotoxicity from molecular bases to clinical perspective. Rev. Colomb. Cardiol. [online]. 2016, vol.23, n.2, pp.104-111. ISSN 0120-5633.  https://doi.org/10.1016/j.rccar.2015.10.002.

Nowadays cancer represents an epidemic that can be considered a public health problem. That is why pharmacological development has emerged for improving survival and remission rates. Nevertheless, this has been obscured by the toxicity of these therapies. Cardiotoxicity is a known adverse event of oncologic therapy that many times limits a correct regimen of administration thus lowering efficacy; therefore, understanding pathophysiological and molecular bases is essential in order to determine preventive and therapeutical measures that can allow a reduction in the incidence of toxicity, without interfering in the efficacy of the cancer therapy. We hereby describe a review of the adverse effects of chemotherapy in the cardiac system, from molecular bases to clinical implications.

Keywords : Heart; Complications; Cardiac failure; Treatment; Free radicals.

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