Abstract

J. ARAUJO, John et al. Intravenous acetaminophen in closure of patent ductus arteriosus in preterm infants. Rev. Colomb. Cardiol. [online]. 2016, vol.23, n.4, pp.340.e1-340.e5. ISSN 0120-5633.  https://doi.org/10.1016/j.rccar.2015.12.002.

We report the case of three 26, 29 and 32 week-old newborns, with a birthweight of 810, 1,300 and 1,670 g respectively, who were clinically diagnosed with patent ductus arteriosus with hemodynamic repercussion. It was confirmed by means of a transthoracic echocardiogram that showed a ductus arteriosus of 1.5, 3.2 and 3.9 mm. Due to their unstable clinical condition, which contraindicated conventional pharmacological closure with nonsteroidal anti-inflammatory medications (NSAIDs) and posed a high surgical risk, it was decided to perform pharmacological closure with intravenous acetaminophen at 15 mg/kg, one dose every 6 hours. Echocardiographic control every 24 hours confirmed total closure of tha ductus arteriosus after 3, 5 and 7 treatment days respectively. Liver enzymes were analysed 24 hours before and 48 hours after administering acetaminophen. All of them had clinical and echocardiographic follow-ups after one, 3 and 6 months which ruled out any reopening of the ductus arteriosus.

Keywords : Ductus arteriosus; Echocardiogram; Cardiac failure.

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