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Revista Colombiana de Cardiología

Print version ISSN 0120-5633


PORTILLA, Alfredo; TORRES, Daniel; MACHADO-DUQUE, Manuel Enrique  and  MACHADO-ALBA, Jorge Enrique. Intervention to rationalize use of losartan. Rev. Colomb. Cardiol. [online]. 2017, vol.24, n.1, pp.8-14. ISSN 0120-5633.


To determine frequency of prescription of losartan over 100 mg/day, to notify the physicians responsible for the healthcare about the limited benefits and to thus achieve a decrease in the number of individuals taking this dose.


Quasi-experimental study, before and after, without a control group, on prescription factors in patients with a diagnosis of arterial hypertension taking losartan between January 1st 2010 (41,624 patients) and December 31st 2014 (75,126 patients). Afterwards, people receiving doses over 100 mg/day were identified. Educational interventions were conducted starting June 2012, and results were measured in terms of the proportion of patients who stopped taking losartan in these doses.


In 2012, 7,205 individuals were identified (12.8% of patients with losartan) with more than 100 mg/day, who after 108 educational activities were reduced to 5,373 by year 2014 (7.1% of patients taking antihypertensive agents; a 25.4% decrease) despite a 29.3% rise in registered participants during the follow-up period. After the intervention, a COP$ 204,293,878 saving was achieved over the course of two years.


Prescriptions of losartan in doses higher as what were deemed effective were reduced, which implies a reduction of both the risk of hyperkalemia and the costs due to taking a higher dose than recommended. It is important to reinforce ongoing medical education activities in order to promote appropriate drug consumption.

Keywords : Arterial hypertension; angiotensin II receptor antagonists; pharmacology; Epidemiology.

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