Objective:

To conduct an updated review of situs inversus totalis and present clinical cases.

Methods:

A review of the main databases was conducted, and the most relevant studies over the last 20 years were included, both in Spanish and English, in all age and ethnic groups,

including:

meta-analysis, systematic reviews, clinical trials, cohort studies and relevant clinical cases. Databases such as EBSCO, Medline, PubMed and SciELO were consulted among others to obtain updated information. Search terms were ‘‘situs inversus’’, ‘‘totalis’’.

Results:

Situs inversus totalis is a rare anatomical variant that involves thoracoabdominal structures, takes part in other situs variants, has a polygenic inheritance pattern, without a direct established relationship; is also an asymptomatic entity, recognised since ancient times.

Conclusion:

Despite being a condition with a low incidence in the population and having an incidental finding, it is important to recognise it as an anatomical variant that can coexist with

concomitant diseases. Although studies exist, more are required with a higher statistical significance. A relationship is found between the cases with the information found in the literature, which leads to a strong research</org>.

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