Abstract

HERNANDEZ, Angélica; DUQUE, Juan; ROSALES, Wendy  and  LIZCANO, Fernando. Molecular perspectives in hypertrophic cardiomyopathy: epigenetic approach from chromatin remodeling. Rev. Colomb. Cardiol. [online]. 2017, vol.24, n.2, pp.146-152.  Epub Aug 24, 2016. ISSN 0120-5633.  https://doi.org/10.1016/j.rccar.2016.04.019.

Epigenetic alterations induced by environmental factors are more relevant each day for cardiovascular diseases. One of the most observed molecular components in hypertrophic cardiomyopathy is the reactivation of fetal genes caused by multiple conditions, including obesity, high blood pressure, aortic valve stenosis and congenital causes. Despite several investigations with the objective of obtaining information regarding molecular components of this condition, its influence in therapeutic strategies is relatively scarce.

Nowadays information is being searched about proteins that modify the expression of the fetal genes that reactivate with this condition. The relationship between histones and DNA has a recognised control in the expression of genes that are subject to the environment and induce epigenetic alterations. Histone deacetylases are a group of proteins that have revealed to play an important role in differentiation the cardiac cell and could be clear components in the development of hypertrophic cardiomyopathy. In this study current knowledge about the influence of these proteins and possible therapeutic plans for hypertrophic cardiomyopathy are revised.

Keywords : Hypertrophic cardiomyopathy; Epigenetics; Histone methylation.

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