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Revista Colombiana de Cardiología

Print version ISSN 0120-5633


ECHEVERRI, Darío; CABRALES, Jaime R.; PORTILLO, Juan Hernando del  and  REY, Dairo. Drug-eluting stents in premature coronary disease in young people with homozygous familial hypercholesterolemia and prior liver transplantation. Rev. Colomb. Cardiol. [online]. 2017, vol.24, n.4, pp.351-360.  Epub Jan 13, 2017. ISSN 0120-5633.

Familial hypercholesterolemia is a genetic disorder characterised by very high cholesterol and low-density lipoproteins serum levels, tendon xanthomas and premature atherosclerosis. Heterozygous form is the most common, with a prevalence of approximately 1 out of 300 to 500 people worldwide, whereas the homozygous, autosomal dominant, is the rarest form, with a prevalence of 1 out of 1 million people. It is characterised by severe hypercholesterolemia leading to premature cardiovascular disease, and it often does not respond to traditional therapy due to the lack of receptors for functional LDL-c. LDL-c levels can exceed between six and ten times the normal values, in which case liver transplantation has become the treatment of choice for patients who do not respond to routine pharmacological therapies. This study presents two cases of homozygous familial hypercholesterolemia in young patients aged 14 and 15, with prior liver transplantation and severe coronary disease in major vessels (anterior descending artery and right coronary artery) who underwent successful implant of a drug-eluting stent.

Keywords : Familial hypercholesterolemia; Coronary disease; Drug-eluting stents; LDL Cholesterol.

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