Introduction:

Cardiac resynchronisation therapy (CRT) is one of the current strategies for patients with heart failure and depressed systolic dysfunction. It has shown to produce a significant reduction in the symptoms, as well as an improvement in left ventricular function and long-term survival.

Objective:

To evaluate the response to CRT after 6 months of follow-up.

Materials and method:

A retrospective, observational, analytical cohort study, with nested case-control analysis, was conducted, which included patients over 18 years of age attending a heart failure clinic, and were carriers of a CRT device. A univariate analysis was performed on the clinical and echocardiographic characteristics. A bivariate analysis was subsequently performed on the variables associated to the treatment response.

Results:

The study included 92 patients with a history of heart failure and an indication of CRT, of whom 32.6% had ischaemic heart disease, and with a mean ejection fraction of 18.9%. There no deaths or heart transplants during the first 6 months of follow-up. Just under half (47.8%) of the patients were considered responders to the therapy, with the remaining 52.2% classified as non-responders. The percentage of patients that did not require hospital admission after the therapy was 51.1%, 65.2% improved functional class, and 68.5% their ejection fraction.

Conclusion:

Just under half (47.8%) of the population studied had an adequate response to CRT, when evaluated combined with the clinical and echocardiographic parameters. This led to a significant improvement in terms of ejection fraction and functional class, including a lower number of hospital admissions due to heart failure, as well as the absence of heart transplants and deaths by cardiovascular cause.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )