Abstract

ALVARADO-GIMENEZ, Juan S.; BERTIN, José H.; FAREZ, Beder G.  and  VEGA, Gustavo G.. Outpatient management of patients with cardiac light chain amyloidosis. Rev. Colomb. Cardiol. [online]. 2023, vol.30, n.1, pp.45-56.  Epub Feb 09, 2023. ISSN 0120-5633.  https://doi.org/10.24875/rccar.22000019.

Primary or light chain (AL) amyloidosis is the most common form of amyloidosis and is characterized by a clonal population of plasma cells that produce a monoclonal lambda or kappa-type light chain, which in some subjects this chain is deposited as amyloid in the organs and tissues, giving rise to clinical manifestations such as proteinuria or nephrotic syndrome, restrictive cardiomyopathy and hepatomegaly. Although considered a rare disease, recent data suggest cardiac amyloidosis is underestimated as cause of common heart diseases or syndromes. In AL amyloidosis, both the hematologic and organ response after treatment, are important to improve clinical outcome. Especially if it improves cardiac function is one of the key aspects in the prognosis of AL amyloidosis. We present the case and review of a 67-year-old female patient, who in the investigation diagnoses anemia and heart failure concludes in the diagnosis of multiple myeloma and cardiac amyloidosis due to light chain deposition.

Keywords : Amyloidosis; Cardiac amyloidosis; Multiple myeloma; Light chains.

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