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CES Medicina
versão impressa ISSN 0120-8705
Resumo
CALDERON FLOREZ, Viviana; MACHADO-DUQUE, Manuel E e MACHADO-ALBA, Jorge E. Profile and safety of metoclopramide use in pediatric patients treated at a second level hospital. CES Med. [online]. 2016, vol.30, n.1, pp.35-45. ISSN 0120-8705.
Introduction: metoclopramide is a prokinetic drug with potential adverse drug reactions which are common in pediatric population; because of this, restrictions have been established for its use in children. The objective was to determine the use and the safety profile of metoclopramide in pediatric patients treated with metoclopramide and to determine the variables associated with the presence or not of adverse drug reactions. Methods: cross-sectional study in under 18 year old patients who were treated for 5 months between 2013 and 2014, in the emergency deparment and observation of a second level of attention hospital in Dosquebradas, Colombia. Results: 142 patients who received metoclopramide were found. The most frequent diagnosis of both income and discharge was diarrhea and gastroenteritis of presumed infectious origin (30.9 % y 28.8 %), 59.1 % of the patients received a higher dose than recommended, seven patients (4.9 %) presented adverse drug reactions; the most frequent comedication was dipyrone (29.5 %) and ranitidine (22.5 %). The variables to weigh less than 10 kilograms (p=0.025) and to get three doses per day (p=0.022) had a statistically significant association with increased risk of some adverse drug reaction, receive a single dose of metoclopramide was associated with reducing the risk of adverse drug reactions (p = 0.014). Conclusions: the Metoclopramide is a frequently used drug in pediatric population despite the current restrictions. Particular attention should be paid to dosage of metoclopramide in children who weigh less than 10 kilograms.
Palavras-chave : Pediatrics; Pharmaepidemiology; Drug Toxicity.