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CES Medicina

versão impressa ISSN 0120-8705


RODRIGUEZ, Javier et al. Probabilistic evaluation of arrhythmic cardiac dynamics with and without metoprolol. CES Med. [online]. 2017, vol.31, n.2, pp.144-154. ISSN 0120-8705.


Based on the theory of dynamic systems and probability theory, highly sensitive clinical methodologies have been developed to differentiate normality, disease and evolution towards cardiac disease.


Holter recordings, 7 normal and 73 with arrhythmia diagnosis with and without therapeutic treatment of Metoprolol, were selected. Probability measures, established in a previous work, were applied for assessing maximum, minimal and average heart rate and beats per hour.


It was found that almost a half of the cases with arrhythmias without beta-blocker therapy exhibited mathematical measures of illness and evolution towards disease, whereas in the treatment group with Metoprolol, three quarters accomplished these features.


More objective mathematical distinctions were achieved between cardiac dynamics treated with and without metoprolol, which is very useful for individual follow-up.

Palavras-chave : Heart rate; Cardiac Arrhythmias; Metoprolol; Cardiology; Theory of dynamic systems.

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