Background.

Dipyrone is an antipyretic, analgesic and antispasmodic, positioned as one of the first options in pain management. The aim was to establish the incidence of adverse effects related to the use of dipyrone in patients hospitalized in a third level hospital in the city of Pereira- Colombia during 2016.

Methods:

A descriptive study that included patients with any adverse effect related to the use of dipyrone. The classification of adverse reactions of Rawlins and Thompson was used. The causal relationship was calculated with Naranjo scale.

Results:

A total of 59 patients were evaluated for adverse reactions with the use of dipyrone, with a mean age of 44.36 ± 21.6 years and 52.5% were women. The reactions occurred mainly in surgical patients (52.5%). The most frequent indication for its use was trauma in 39 % of cases, followed by some surgical procedure (25.4%). In 28.8% of the cases, the event reappeared after a new administration of dipyrone during the same hospitalization. A case of granulocytopenia was presented. The incidence of adverse events with dipyrone was 1.4 per 1000 patients.

Conclusion:

Adverse reactions related to the use of dipyrone are a rare finding despite the wide use of the drug. Hematological toxicity should be considered when prescribing dipyrone. Patient safety protocols should be improved in order to reduce possible adverse events related to the administration of medications.

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