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Acta Neurológica Colombiana

Print version ISSN 0120-8748

Abstract

GONZALEZ TRUJILLO, Fernando et al. Update on treatment and pathology of gangliogliomas: A not so benign tumor. Acta Neurol Colomb. [online]. 2010, vol.26, n.2, pp.112-119. ISSN 0120-8748.

SUMMARY Gangliogliomas (GG) are defined as mixed tumors compose from glia and neurons usually with a benign biological behavior. However, there are reports of GG that differentiate toward high grade glioblastoma. This change is observed more frequently in the glial component but neuronal part could be also involved. Pathophysiology is better understood currently, part of this is represented by the identification of changes in genes at p53 and the definition of tumoral markers like Ki 67, both of them important at the moment of prognosis definition and therapeutic decisions. Treatment of these tumors implies broad surgical resection due to high morbidity of them. Chemotherapy and radiotherapy are options which improve survival of patients who suffer anaplastic varieties. This paper review recent changes in histological classification and recent contributions on histology, inmunochemistry, genetics and treatment. In addition we discuss two cases in two different ages and stages showing the usual benign behavior and the transformation to a multiform gliobastoma, along with a detailed pathological review.

Keywords : Pathology; central nervous system; neurology.

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