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Acta Neurológica Colombiana

Print version ISSN 0120-8748


TAMAYO-ORREGO, Lukas; MOSCOSO ARIZA, Óscar H  and  RESTREPO, Francia. Evoked potentials in two cases of open-lip schizencephaly. Acta Neurol Colomb. [online]. 2010, vol.26, n.3, pp.155-160. ISSN 0120-8748.

Schizencephaly is a brain malformation caused by an abnormality of neuronal migration. It is characterized by a cleft spanning the pallium from the pial surface to the ventricular system that is lined by cortical gray matter. If the edges of the cortex around the cleft are in contact with each other, the lesion is named closed-lip schizencephaly; when the cleft borders are not in contact, the lesion is termed open-lip schizencephaly and the cleft is filled with cerebrospinal fluid. The most frequent clinical manifestations of the disease are psychomotor delay, motor impairment and epilepsy. This is a report of two cases of patients with diagnosis of open-lip schizencephaly, the first one unilateral and the second one bilateral . Various studies of evoked potentials (ERP) by different sensory modalities were done, correlations between clinical data, ERP and brain images were obtained too. Each case presented one specific pattern in the somatosensory evoked potentials that can be used to suspect haemispheric malformations. Auditory and visual evoked potencials were not useful to discriminate between different types of schizencephaly.

Keywords : Schizencephaly; evoked potentials; brain.

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