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Acta Neurológica Colombiana

versión impresa ISSN 0120-8748


ROMERO VANEGAS, Sara Julieta et al. Verbal episodic memory at the preclinical and early phases of familiar early - onset Alzheimer disease caused by E280A mutation at PS1. Acta Neurol Colomb. [online]. 2010, vol.26, n.4, pp.177-194. ISSN 0120-8748.

INTRODUCTION. Early pre-clinical diagnosis is the greatest challenge faced by researchers into dementia. Despite several reported cognitive markers, the episodic verbal memory has not been widely studied in populations with biological markers. OBJETIVE. The aim of this study was determine the possible alterations in early episodic verbal memory in a two groups of participants at the risks of developing Early Familial Alzheimer's disease, when was compared with a control group in two test: the MIS (Memory Impairment Screen) and the MCT (Memory capacity test). MATERIALS AND METHODS. The sample group consisted of 48 participants who were genotyped for the E280A PS1 mutations. They were further divided into three groups: 14 asymptomatic carriers, 11 carriers subjects with MCI (Minimal cognitive impairment) and 23 healthy non-carriers. The selection process was performed using the Minimental and the GDS (Global deterioration scale), FAST(Functional Assessment Staging de Reisberg) scales and scale subjective memory complaints. The samples were subsequently administered the MIS and the MCT and variables such as free recall were recorded. RESULTS. Significant differences between groups of carriers, obtaining evidence MCI group that has an alteration in the episodic verbal memory, originated in the encoding phase. However, in asymptomatic carrier group it was observed that the alteration is in the evocation phase. CONCLUTION. The MIS and MCT were useful to discriminate between carriers with MCI and healthy carriers. These tests are characterized by short, easy administer ability, and low cost. It is proposed that this method is used in neuropsychological assessments protocols, in order to effectively assess pre-clinical dementia. It is also suggested to use a larger sample group, to validate the test applied to the Colombian context.

Palabras clave : Early diagnosis; Alzheimer disease psicological; Neuropsychological test; Presenilin-1.

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