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Acta Neurológica Colombiana

versão impressa ISSN 0120-8748


PRETELT, Felipe; PATRICIA MILLAN, Sonia  e  GIL, Laura. Acute hemorrhagic leukoencephalitis: clinical presentation, radiologic and neuropathologic features. Acta Neurol Colomb. [online]. 2013, vol.29, n.4, pp.289-294. ISSN 0120-8748.

Acute hemorrhagic leukoencephalitis or Hurst disease is a rare disorder characterized by its severe neurological involvement, rapid progression and fatal outcome in a few days. The disease is usually a post infectious condition. Under microscope, it is identified by a perivenular demyelination and a diffuse hemorrhagic necrosis. This entity is thought to represent a hyperacute severe form of acute disseminated encephalomyelitis, which is an inflammatory autoimmune post infectious disorder. We describe the case of an adult woman, who visits the emergency room with migraine-like symptoms and a previous clinical history of similar headaches. Twelve hours later she developed focal neurologic findings, stupor and signs of endocraneal hypertension, her clinical status continued to worsen and in 96 hours she succumbed. The autopsy confirm acute hemorrhagic Leukoencephalitis. Reviewed clinical, radiological and pathological characteristics of this uncommon disease.

Palavras-chave : Acute Hemorrhagic Leukoencephalitis; Hurst Disease; Encephalomyelitis Acute Disseminated; Post infectious Encephalomyelitis (MeSH).

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