Abstract

TREJO PAREDES, María Camila; GARCIA VALENCIA, Jenny  and  ARANGO VIANA, Juan Carlos. Triple-negative gliomas. Acta Neurol Colomb. [online]. 2014, vol.30, n.3, pp.186-192. ISSN 0120-8748.

Among the primary neoplasms of the central nervous system, gliomas are the most common. The tumour classification system proposed by the World Health Organization assigned four grades of increasing malignancy to gliomas based on some histological features. However, this classification has several limitations, one of which is the poor prognostic prediction which affects the therapeutic approach. Recent studies have shown the prognostic value of specific molecular alterations. The most representative of these are the 1p19q deletion and mutations of the genes encoding IDH and TP53. Mutations of IDH1/2 (80% of low-grade diffuse gliomas, grade II), the 1p19q deletion (70% of oligodendrogliomas) and mutations of TP53 (60% diffuse astrocytomas) are associated with better survival. These three immunohistochemical markers greatly contribute to the classification of gliomas and must be checked routinely as prognostic markers.

Keywords : Gliomas; prognosis; molecular classification; isocitrate dehydrogenase; 1p19q deletion; TP53.

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