SciELO - Scientific Electronic Library Online

vol.31 número1Sindrome de Villaret y paraganglioma cervical: Reporte de caso con consideraciones especialesNeuropsicología y la localización de las funciones cerebrales superiores en estudios de resonancia magnética funcional con tareas índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados




Links relacionados

  • En proceso de indezaciónCitado por Google
  • No hay articulos similaresSimilares en SciELO
  • En proceso de indezaciónSimilares en Google


Acta Neurológica Colombiana

versión impresa ISSN 0120-8748


BENAVIDES, David; RODRIGUEZ, Laura Cristina; RESTREPO, Jorge  y  VARGAS B, Daniela. Pathophysiology of migraine: vascular theory, true or not?. Acta Neurol Colomb. [online]. 2015, vol.31, n.1, pp.84-91. ISSN 0120-8748.

Migraine is a highly prevalent disease; it is disabling, and sometimes difficult to manage. For decades, many theories have been proposed to explain its course, its association with a genetic component and with different risk factors. There is currently no single and exact pathophysiology that accounts for all events, and strong evidence has been showing that the oldest theory believed to be mostly true, i.e. the vascular theory, is actually incorrect, because it does not explain the totality of the events. However, various mechanisms have been proven to exist, which together, provide insight into alterations, such as structural changes involving neuropeptides, sensitization, and neurogenic inflammation.

Palabras clave : Migraine; Calcitonin Gene-Related Peptide; Serotonin (MeSH); Trigeminal System; sensitization; glutamate; neurogenic inflammation; vascular theory.

        · resumen en Español     · texto en Español     · Español ( pdf )