Resumo

TORO GONZALEZ, Gabriel; SIERRA ZULETA, Uriel Esteban  e  GOMEZ GROSSO, Luis Alberto. Teoría Prión - Enfermedades Priónicas. Acta Neurol Colomb. [online]. 2015, vol.31, n.1, pp.101-112. ISSN 0120-8748.  https://doi.org/10.22379/2422402215.

There has been tremendous progress in the identification, prevention, control and study of prion diseases. This update presents a brief Summary of the history of Prion theory and the national participation in relation to human and animal health, which may partly explain why we have presence in our country of Creutzfeldt-Jakob disease (CJD) only in its sporadic variant and an absence of bovine spongiform encephalopathy (BSE or "mad cow disease") until today. These also rule out the possible occurrence of variant CJD (vCJ), which is a zoonotic disease. Finally, as recent advances in basic research, we show a similarity in prion amyloid aggregate structure formed by prions, ßA amyloid aggregates of Alzheimer's disease and alpha synuclein of Parkinson disease, which until recently began being investigated. A mechanism of neural toxicity, nucleation, transmission misfolding and restriction of transmission between species is discussed.

Palavras-chave : Spongiform encephalopathies; Lentiviral diseases; Prion diseases; Molecular structure; Amyloid; Alzheimer's disease.

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