SciELO - Scientific Electronic Library Online

vol.31 número2Tiempo puerta-TAC antes y después de la implementación de una vía clínica para la atención de los pacientes que ingresan con diagnóstico de ACV isquémico hiperagudo al servicio de urgencias del Hospital de San JoséCaracterísticas clínicas y diagnósticas de tuberculosis meníngea en adultos, Bogotá (Colombia) índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados




Links relacionados

  • En proceso de indezaciónCitado por Google
  • No hay articulos similaresSimilares en SciELO
  • En proceso de indezaciónSimilares en Google


Acta Neurológica Colombiana

versión impresa ISSN 0120-8748


GARCIA, Ronald G et al. Association of C-reactive protein and nitric oxide levels with the prognosis of acute ischemic stroke. Acta Neurol Colomb. [online]. 2015, vol.31, n.2, pp.141-149. ISSN 0120-8748.

Introduction: Inflammation and alterations in the bioavailability of nitric oxide (NO) have been involved in the pathophysiology of cerebrovascular disease. Objective: The aim of the study was to determine the prognostic value of measuring NO metabolites and inflammatory markers in patients with acute ischemic stroke. Materials and methods: A total of 158 patients with acute ischemic stroke were included in an observational cohort study. Between 48 and 72 hours post admission, a fasting blood sample was taken to determine the biochemical profile, inflammatory markers (CRP, IL1-β, IL6, TNF-α) and nitrites/nitrates plasma levels. The cohort's follow-up was conducted for two years to determine the occurrence of a new event (stroke, myocardial infarction, heart failure) or death of vascular origin. Comparisons between groups were made using the log-rank test. A Cox multivariate regression analysis permitted to determine factors independently associated with the outcome. Result: The mean age was 70.5 ± 12.8 years. 39.2% of the subjects presented the outcome during the first 24 months of follow-up. CRP levels > 12 mg/L (HR 2.22, 95% CI 1.07-4.59) and a score > 13 on the NIHSS scale at admission (HR 2.81 95% CI 1.46-5.41) were significantly associated with an increased risk of a new event. The combination of CRP levels < 12 mg/L and nitrites/nitrates levels < 35.5 mmol/L was identified as a protective factor (HR 0.21, 95% CI 0.06-0.71). Conclusion: This study demonstrates that the determination of CRP and NOx levels could be beneficial in clinical practice to stratify the risk of future events or death of vascular origin in acute ischemic stroke patients.

Palabras clave : Acute ischemic stroke; inflammation; C-reactive protein; nitric oxide; nitrites/nitrates.

        · resumen en Español     · texto en Español     · Español ( pdf )