Abstract

ORTIZ DE LA ROSA, Johann Sebastián; RAMIREZ, Silvana  and  RUEDA, María Camila. Use of Lacosamide in pediatric population with refractory epilepsy as an adjunctive therapy, a systematic review of literature. Acta Neurol Colomb. [online]. 2015, vol.31, n.2, pp.217-222. ISSN 0120-8748.  https://doi.org/10.22379/2422402232.

Objetive: to present the evidence published about the usefulness of lacosamide in pediatric patients with refractory epilepsy, in order to explain its use in this population. Methods: we conducted search in PubMed, Embase, Cochrane library and Scielo and found 18 articles that fulfilled the inclusion criteria. Findings: lacosamide, is one of the newer AED (Antiepileptic Drugs) approved for focal refractory and focal onset epilepsies as an add on treatment in patients older than 16 years. However there is growing evidence of its use, security and efficacy in pediatric population from 4 years and above. Adverse effects do not differ from others found in others AED with success seizure free rates between 8 and 40%. Studies revisited had major issues on long term following. In addition, lacosamide improves behavioral and motor skills in children despite seizure control. Conclusions: Studies shows lacosamide as a safe option in pediatric patients with focal onset and refractory epilepsies as an add on therapy given its seizure control, safety profile, low rate of adverse effects and interaction between others medications, however larger and long term studies are needed.

Keywords : Child; refractory epilepsy; lacosamide; pediatrics; safety; treatment efficacy.

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