Abstract

HENAO LOPEZ, Adriana Isabel; PEREZ ZULUAICA, Juan Camilo  and  CORNEJO OCHOA, José William. Encephalopathy and bilateral globus pallidum infarction secondary to disulfiram poisoning. Case Reports in Pediatrics. Acta Neurol Colomb. [online]. 2015, vol.31, n.3, pp.280-283. ISSN 0120-8748.

Disulfiram (Antabuse ®) is a drug that is widely used in patients with chronic alcohol consumption as part of treatment for alcoholism, in order to produce unpleasant symptoms when mixed with ethanol, acetaldehyde increased. Although there have been cases of poisoning even without alcohol intake at therapeutic doses and overdose most commonly in adults, few cases have been reported in children. We present a Child with disulfiram intoxication, who presented in acute sleepiness, progressing to stupor concomitantly presented seizures, vomiting, dehydration, rigidity, tremor and sweating; in output with severe neurological sequelae characterized by bilateral dystonia and pyramidal signs as a result of bilateral basal ganglia lesion documented by imaging.

Keywords : Basal Ganglia; Disulfiram Intoxication; Globus Pallidum; Neurotoxicity (MeSH).

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