SciELO - Scientific Electronic Library Online

 
vol.31 issue3Frequent falls Neuroimaging in a patient with Progressive Supranuclear PalsyPolineuropatía asociada a infección por VIH. Revisión del tema y presentación de un caso: Polyneuropathy associated to VIH infection. Review of the topic and case report author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google

Share


Acta Neurológica Colombiana

Print version ISSN 0120-8748

Abstract

GONZALEZ M, Guillermo et al. Sporadic Creutzfeldt-Jakob disease: two case reports. Acta Neurol Colomb. [online]. 2015, vol.31, n.3, pp.291-298. ISSN 0120-8748.

Creutzfeldt-Jakob is the most common spongiform encephalopathy in humans and the prototype of prions diseases. Astrogliosis and degeneration of the gray matter are the histological features. Typically starts with nonspecific prodromal symptoms that progressing to dementia with myoclonus and ataxia. We present two cases of women in middle age with progressive cognitive impairment, motor difficulties, language disorders and myoclonus that lead to death. EEG slow periodic triphasic waves and elevated protein tau and CSF14-3-3 support for The National Prion Disease Pathology Surveillance Center - Cleveland, all these findings define the conditions for the clinical diagnosis of prion disease. The differential diagnosis in the context of rapidly progressive dementia is broad including infections, poisoning, metabolic disorders, autoimmunity, vascular disease and neoplasms that could explain a possible underreporting in regional statistics. There is a possible risk association between disease and Medical Pathologists that although discussed could limit the study of histological specimens that are key to definitive diagnosis. Despite the public health importance of these conditions the current model of health limits the comprehensive management of patients.

Keywords : Astrogliosis; Creutzfeldt-Jakob; dementia; myoclonus; prions; protein 14-3-3 (MeSH).

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )