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Acta Neurológica Colombiana

Print version ISSN 0120-8748


GONZALEZ TRUJILLO, Fernando et al. Primary leptomeningeal lymphoma . Report of three cases and review of the literature. Acta Neurol Colomb. [online]. 2015, vol.31, n.4, pp.432-439. ISSN 0120-8748.

Primary Leptomeningeal lymphmoma (PLML) is a low frequency neoplasm representing 1% to 2,4% of primary lymphomas of the central nervous system (CNS). The most frequent histological variety is the extranodal marginal zone lymphoma (MALT lymphoma), but other variants are reported such as diffuse large cell B-cell lymphoma (DLBCL). The location and extent determine the clinical manifestations. In radiology, images with contrast are preferred to difference from meningiomas which are the main differential diagnosis; nevertheless surgery and histology confirm the diagnosis. Chemotherapy is the mainstay of treatment and radiation therapy is a secondary alternative. The purpose of this paper is to present three cases of PML, the radiological variants and to conduct a focused literature review with treatment of this pathology.

Keywords : Central nervous system neoplasms; immunohistochemistry; lymphomas; meninges.

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