Resumo

PRETELT, Felipe et al. Creutzfeldt-Jakob review based on two clinical cases in Hospital Universitario San Ignacio. Acta Neurol Colomb. [online]. 2016, vol.32, n.2, pp.134-139. ISSN 0120-8748.

Creutzfeldt-Jakob disease is a fatal and untreatable neurodegenerative disorder that is part of the so-called spongiform encephalopathies, which is caused by the abnormal accumulation of PrP protein (called PrPSc) in the central nervous system. The most common human prion disease is sporadic form of Creutzfeldt-Jakob, whose appearance has been associated with environmental effects or unknown and random genetic events that result in the spontaneous production of PrP in the brain. In this work we will present two Clinical cases of two woman who visited the emergency room of the hospital Universitario San Ignacio, in which a rapidly progressive encephalopathy caused by Creutzfeldt-Jakob disease is suspected.

Palavras-chave : diffusion weighted imaging; Creutzfeld-Jakob disease; 14-3-3 protein; Tau protein; rapidly progressive dementia; RMN DWI.

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