Abstract

CASTANO-JARAMILLO, Lina María; MESA-MUNOZ, Catalina; GIRALDO-ARDILA, Natalia  and  VASQUEZ TRESPALACIOS, Elsa María. Stridor in neonates with hypoxic encephalopathy undergoing therapeutic hypothermia. Acta Neurol Colomb. [online]. 2016, vol.32, n.4, pp.285-289. ISSN 0120-8748.  https://doi.org/10.22379/24224022109.

Summary Introduction: Therapeutic hypothermia used for term and late preterm newborns with hypoxic ischemic encephalopathy has shown decrease in mortality and neurocognitive impairment, stridor has been recently described as an adverse effect of this therapy. Results: In 34 newborns with hypoxic ischemic encephalopathy treated with therapeutic hypothermia in a neonatal unit, we found male sex and Sarnat II hypoxic encephalopathy predominance, 12 patients (35.3%) developed stridor. 7 out of the 34 patients received steroid therapy previous to extubation and only 1 (14%) presented stridor. The patients that didn't received steroids 40% presented stridor. Out of the patients that developed stridor 33% required intubation because of this cause. Conclusion: Our series didn't find difference in the use of adrenaline or steroids previous to extubation to prevent stridor in hypothermic patients. We also had 2 cases that developed stridor without airway manipulation, these supports that inflammatory mechanism is not the only one involved in the development of stridor in newborns under cooling therapy.

Keywords : Infant; Newbor; Hypothermia; Induced; Hypoxia-Ischemia; Brain/therapy; Respiratory Sounds.

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