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Acta Neurológica Colombiana

Print version ISSN 0120-8748


HERNANDEZ-RUIZ, Eder A. et al. Intravenous thrombolysis in patients with ischemic stroke: Experience from a Colombian Caribbean Hospital. Acta Neurol Colomb. [online]. 2017, vol.33, n.1, pp.3-7. ISSN 0120-8748.


The ischemic stroke guidelines establish within the management algorithm the implementation of intravenous thrombolytic therapy as one of the strategies to approach the acute event that has been shown to reduce levels of disability in patients.


To describe the impact of intravenous thrombolysis performed on patients with ischemic stroke, taking into account functionality and prognosis measuring scales.


We conducted a descriptive longitudinal study on patients to whom intravenous thrombolysis were performed at the Fundación Hospital Universidad del Norte ( October 2011 - March 2016) taking into account the demographics aspects as well as risk factors including a 30 and 90 day follow up to determine prognosis and mortality using the modified Rankin scale.


The study consisted of 27 patients whose average age was 65 years, finding a higher prevalence within female patients and A frequent risk factor of hypertension (19/27). Initial management was performed according to the institutional protocol from the stroke unit. Average times were shown at each stage of care, from the onset of symptoms to thrombolysis. During the intervention, some complications were documented which justified the suspension of the treatment. There was hemorrhagic transformation of stroke reported leading to secondary death. Functionality was assessed with the NIHSS scale at patient's admission and discharge, prognosis and mortality were assessed with a modified Rankin scale, which showed that more than 50% of the patients scored between 0 and 1 at 90 days post-thrombolysis.


The study has limitations in order to establish conclusions statistically significant, but it does reflect the experience of a university center with an effective therapeutic intervention and looks to create a database in the region that can be use like a reference for other studies.

Keywords : Ischemic stroke; Fibrinolitic therapy; Alteplase; Stroke unit.

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