Abstract

PRETELT, Felipe; MILLAN, Sonia Patricia  and  NOVOA, Mónica María. Seronegative Myasthenia Gravis: A Literature Review. Acta Neurol Colomb. [online]. 2017, vol.33, n.1, pp.46-51. ISSN 0120-8748.  https://doi.org/10.22379/24224022130.

In 1976 antibodies against acetyl-choline receptor were identified on the serum of patients with myasthenia gravis. However, some years later, it became clear that about 20% of patients with generalized MG and an electro physiologic disorder on the neuromuscular junction did not express these antibodies by radioimmunoassay (RIPA). These cases represent seronegative myasthenia gravis (SNMG). The diagnosis of these patients is difficult, given the absence of detectable autoantibodies on serum and the lack of sensitive neurophysiologic tests. Recently, a new method based on cellular assays shows an increase on detection of seropositive MG from cases, which were initially diagnosed as seronegative. This article reviews the physiopathology of seronegative MG and gives an update on the latest advances concerning its diagnosis. It also hopes to approach the current general context of the illness in Colombia.

Keywords : Autoimmune Diseases of the Nervous System; Myasthenia Gravis; Autoimmune; Experimental; Nervous System Diseases; Neuromuscular Diseases; Neuromuscular Junction Diseases (MeSH).

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