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Acta Neurológica Colombiana

versão impressa ISSN 0120-8748


RODRIGUEZ-CARRILLO, Juan Camilo  e  IBARRA, Melisa. Depression and other affective disorders in Parkinson's disease. Acta Neurol Colomb. [online]. 2019, vol.35, suppl.1, pp.53-62. ISSN 0120-8748.

Non-motor symptoms are frequent in Parkinson's disease (PD), being depression, anxiety and apathy symptoms very prevalent in this population. These symptoms have been shown to be determinants of quality of life in patients with PD, resulting in reduced quality of life, poorer functional status and worse cognitive function, and have been associated with an increase in mortality. Various neurotransmitters systems, such as dopaminergic, serotonergic and noradrenergic pathways, may contribute to the high onset of depression in PD. There are several scales that serve as tools to monitor changes over time and determine the effect of therapeutic strategies in these patients. The therapeutic strategy can be approached from the pharmacological and non-pharmacological point of view. Tricyclic antidepressants, serotonin reuptake inhibitors and mixed serotonin and norepinephrine inhibitors have shown effectiveness. There are also positive reports of non-pharmacological options such as transcranial magnetic stimulation, cognitive behavioral therapy, and deep brain stimulation surgery, however the latter require more evidence. Anxiety is related to worsening of motor symptoms and is frequently associated with depressive symptoms. As a treatment, antidepressants with anxiolytic profile and benzodiazepines are commonly used. Apathy is associated with advanced age, worse cognitive function, increased motor symptoms, more disability and lower quality of life with a greater burden for the caregiver.

Palavras-chave : Parkinson's disease; depression; anxiety; apathy; Antidepressive Agents (MeSH).

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