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Acta Neurológica Colombiana

Print version ISSN 0120-8748On-line version ISSN 2422-4022


COTUA URZOLA, Juan Camilo; BLANCO CASTIBLANCO, Luis Alfredo  and  VERGARA RETAMOZA, Ruben Mauro. Candida meningoencephalitis in an immunocompetent patient: Case report. Acta Neurol Colomb. [online]. 2020, vol.36, n.4, pp.243-246.  Epub Jan 17, 2021. ISSN 0120-8748.


Fungal infections of the central nervous system are increasingly frequent due to the increase in populations at risk. They are mainly opportunistic, and uncommon in non-immunocompromise patients.


A 28-year-old man, without a significant medical and surgical history, consulted the emergency department for refractory headache, accompanied by fever and meningeal signs, a lumbar puncture lead to the subsequent microbiological finding of Candida glabrata in cerebrospinal fluid. Immunocompromise was ruled out, including HIV coinfection, collagen, neoplasms and even lack of immunization during childhood.


About 70,000 formally described fungal species are estimated, of which 300 could show virulence in humans, with multiple forms of presentation in the central nervous system, mainly meningitis, encephalitis, hydrocephalus, brain abscess and stroke, all conditioned due to a predisposing factor or immune status of the host, even considering some degree of immunodeficiency on Toll like receptors, which limit the binding to PAMPs and subsequent progression of infection at the height of the CNS.

Keywords : Meningoencephalitis; Fungal meningitis; Encephalitis; Candidiasis (MeSH).

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