SciELO - Scientific Electronic Library Online

vol.36 issue4Candida meningoencephalitis in an immunocompetent patient: Case reportCarotid web: "septo o banda carotidea": Two case reports author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google


Acta Neurológica Colombiana

Print version ISSN 0120-8748On-line version ISSN 2422-4022


FERNANDEZ YEPEZ, Luis José; BLANCO CASTIBLANCO, Luis Alfredo; FERNANDEZ FERNANDEZ, Elias José  and  FERNANDEZ FERNANDEZ, Erwin Javier. Induced parkinsonism for telmisartan: case report. Acta Neurol Colomb. [online]. 2020, vol.36, n.4, pp.247-249.  Epub Jan 17, 2021. ISSN 0120-8748.


Parkinsonism is a clinical syndrome characterized by tremor, rigidity, and bradykinesia due to alteration in the basal-ganglia dopaminergic circuit, specifically at the nigrostriatal level. The following is a case of parkinsonism induced by telmisartan.


A 78-year-old man with a 2-year history of Parkinson's disease of controlled evolution with levodopa, pramipexole ER, amantadine was admitted to the emergency department due to worsening of parkinsonism in the two weeks prior to consultation. He had a history of cerebral infarction in the territory of the left posterior cerebral artery, chronic arterial hypertension, and type 2 diabetes mellitus. On neurological examination, he presented bradykinesia and severe stiffness in all four limbs with significant limitation of gait, associated with myoclonus. Infectious and metabolic alterations and acute lesions were ruled out in the brain tomography, so telmisartan was suspended, after which the symptoms improved.


Drug-induced parkinsonism is the first cause of this syndrome, and the action they exert on dopaminergic receptors has been described in several pharmacological models. Telmisartan-induced parkinsonism is considered triggered by dopaminergic disruption secondary to angiotensin II receptor antagonism at the periaqueductal gray substance level.

Keywords : Angiotensin II Type 1 Receptor Blockers; Hypertension; Telmisartan; Parkinsonian Disorders.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )