Abstract

FERNANDEZ, Rafael; TOBON, Diego Mauricio; OSORNO, Katiana  and  ZULUAGA, Oscar Eduardo. Genetic polymorphism for interleukin-1ß as a modulator of bone resorption processes. CES odontol. [online]. 2012, vol.25, n.1, pp.92-101. ISSN 0120-971X.

Abstract Genetic factors influence inflammatory and immune responses in general, and individuals may respond differently to common environmental challenges. Therefore the genetic profile for every individual module or influence that response. Interleukin 1ß (IL-1 ß) is a potent activator of osteoclastic activity and genetic variation of the protein, known as polymorphism, may increase its effect, which would negatively affect the prognosis of dental treatment. The study of genetic polymorphisms of interleukins has become a topic of great interest and academic debate in different areas of health, given the importance they seem to have as modulators of bone resorption processes. Because of the genetic polymorphisms might help explain the different responses to endodontic treatment in different patients, the purpose of this literature review is to update previously published information regarding genetic polymorphism.

Keywords : Genetic polymorphism; Interleukin-1ß; Cytokines; Apical periodontitis; Periodontal disease.

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