Resumo

TAMAYO-CABEZA, Guillermo; MADERA-ANAYA, Meisser  e  GONZALEZ-MARTINEZ, Farith. Oral cancer and its relation with the 18kda mitochondrial translocator protein. CES odontol. [online]. 2017, vol.30, n.1, pp.17-29. ISSN 0120-971X.

Abstract Oral cancer has a high incidence and mortality rate globally. Despite the advances in the diagnosis and prognosis of this disease, a 5 years survival rate still remains, which makes it necessary to study diagnostic methods capable to detect the disease in early stages. That is why advances in proteomics and immunohistochemistry had allowed the identification of various biomarkers, including the 18 kDa mitochondrial translocator protein (TSPO), which is involved in some cellular processes, such as cholesterol transport, cellular proliferation and apoptosis. It has been reported the altered TSPO values in various types of cancer, as well as the presence of TSPO in saliva of subjects with oral cancer, which represents an opportunity to understand the oral carcinogenic process and identify new alternatives for the diagnosis of this disease. The objective of this review is to present theoretical aspects related to TSPO as a biomarker to study in subjects with oral cancer, considering its implication in the apoptosis mechanism and participation in oxidative stress.

Palavras-chave : Mouth neoplasms; TSPO Protein; biomarkers; oxidative stress.

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