Abstract

SANDOVAL-VIDAL, Hector Paulo. Genetic Variations, Polymorphisms and external apical root resorption associated with orthodontic treatments. Literature review. CES odontol. [online]. 2018, vol.31, n.1, pp.47-56. ISSN 0120-971X.  https://doi.org/10.21615/cesodon.31.1.5.

External Apical Root Reabsorption (EARR) is a common and undesiderable orthodontic treatments sequel, but it may also occur in absence of orthodontic treatment. The origin, extent and severity of EARR during orthodontic treatment are multifactorial, involving both biologic and environmental factors. Genetic factors represent at least 50% of the variation in EARR. The genetic variation in patients undergoing orthodontic treatments has been reported in studies of heritability, in vitro, retrospective and meta-analysis, among others, in order to introduce the genetic variables and polymorphisms, helping to explain the different responses to orthodontic treatment. Genetic polymorphisms may explaining different responses to orthodontic treatment in patients. The study of genetic polymorphisms has become a topic of great interest and debate, because of the importance they seem to have as modulators of bone reabsorption processes. For this reason, the objective of this article is to make a review about the main genetic variables and polymorphisms in association with EARR in patients treated orthodontically.

Keywords : root resorption; genetic predisposition; polymorphism; genetic.

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