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Revista Colombiana de Gastroenterologia

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OLIVEROS, Ricardo  and  GRUPO DE PATOLOGIA et al. Evaluación de la concentración sérica de pepsinógeno como método de tamizaje para gastritis atrófica y cáncer gástrico. Rev Col Gastroenterol [online]. 2003, vol.18, n.2, pp.73-77. ISSN 0120-9957.

Gastric cancer has become a health problem in Colombia, because of its very high incidence and late diagnosis. Only 5% of all gastric cancers reported are diagnosed at an early stage. For these reasons a sensitive, adequated cost-effectiveness and with compliance screening program is required. In Japan the I and II pepsinogen tests have proved to be more effective than the fluoroscopic method for the detection of gastric cancer, the rate of detection being of 0.168% vs the 0.066% obtained fluoroscopically. Based on this evidence, we decided to evaluate the use of the pepsinogen tests in two groups as follows: 66 gastric cancer patients and 110 members of the general population. From all of them we obtained blood samples for testing PEP I and H. pylori antibodies, followed by endoscopy and biopsies. We defined the best cut-off point for PEP I using a ROC curve and found that < 150ng/ml was the best cut-off point with sensitivity of 84.3% and specificity of 71.3%. Thus we concluded that PEP I is a good method for detecting chronic atrophic gastritis and gastric cancer, but also due to the high H. pylori infection prevalence (97%) found the PEP II test must be performed in our population.

Keywords : Screening; pepsinogen; atrophic gastritis; gastric cancer.

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