Abstract

MARTINEZ M, Julián David; HENAO R, Sandra C  and  GRANADOS, Carlos. The corporal atrophic chronic gastritis and the age. Rev Col Gastroenterol [online]. 2007, vol.22, n.1, pp.17-22. ISSN 0120-9957.

A study of cases and controls of 315 patients was realized. Endoscopic biopsies of the gastric body were taken. Following the Sidney methodology, histology changes of chronic gastritis, of its activity, of atrophy presence, of intestinal metaplasia and infection by Helicobacter pylori were studied. Using the multivariate analysis, a positive association was found between greater age of patients and corporal gastric atrophy changes. For patients older than 65 years of age an OR of 3.33 (IC 95% 3.03-3.64) was observed. A similar situation was observed for changes of intestinal metaplasia with an OR 2.97 (IC 95% 2.70-3.24). It was observed that the infection due to Helicobacter pylori decreases with age for people less than 40 years old OR of 1.72 (IC 95% 1.60-1.84), between the ages of 40 and 64 years old OR 0.84 (IC 95% 0.80-0.88), and for older than 65 years OR of 0.63 (IC 95% 0.58-0.68) and it is strongly associated with the gastric inflammation activity OR 27.63 (IC 95% 24.63-30.63). These results are compatible with the hypothesis that the corporal atrophic chronic gastritis is a charge related to human aging.

Keywords : Chronic gastritis; atrophy; intestinal metaplasia; age; Helicobacter pylori.

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