Resumo

LIZARAZO RODRIGUEZ, Jorge Iván. Pathogenesis of pancreatic cancer. Rev Col Gastroenterol [online]. 2008, vol.23, n.4, pp. 391-399. ISSN 0120-9957.

Pancreatic Adenocarcinoma is a lethal disease for which early detection has not improved survival rates. Studies in the last two decades have shown that pancreatic cancer is fundamentally a genetic disease caused by inherited germ lines and acquired somatic mutations in genes associated with cancer. Multiple alterations of genes that are important in the progression of pancreatic cancer have been identified. It is possible that better understanding of these alterations will facilitate identification of new biomarkers for early detection and may lead to novel drug targets.

Palavras-chave : Pancreatic cancer; genetics; pathogenesis; review.