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Revista Colombiana de Gastroenterologia

Print version ISSN 0120-9957


GARCIA DEL RISCO, Fernando; CAMARGO, Juan Manuel  and  ESPANA ARRIETA, Harold. Cholestatic hepatitis induced by flutamida: Presentation of a case. Rev Col Gastroenterol [online]. 2009, vol.24, n.4, pp.408-412. ISSN 0120-9957.

Flutamide is a nonsteroidal antiandrogen, used like therapy a long term for the prostate cancer. Between the indirects effects the hepatic toxicity is included, which is very rarely reported. The case of an adult of 71 years old with prostate cancer appears that develops episode of cholestatic hepatitis during treatment with flutamide. After to suspend flutamide the patient it recovers progressively his hepatic function, but he presented a recurrence more severely upon reintroduction of the drug. The resumption of the treatment after a first episode of toxic hepatitis is not justified and is necessary to consider the hepatic toxicity of the drug, when it is decided to indicate it like treatment.

Keywords : Flutamide; hepatotoxicity; cholestatic hepatitis; prostate cancer.

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