Resumo

PARAMO HERNANDEZ, David B; OTERO REGINO, William  e  PINEDA OVALLE, Luis F. Hepatic fibrogenesis. Rev Col Gastroenterol [online]. 2010, vol.25, n.2, pp. 187-197. ISSN 0120-9957.

Progress achieved in chronic liver disease treatment has also generated increased interest in clarifying the mechanisms underlying the development of hepatic fibrosis. After a liver injury activation of hepatic stellate cells (HSC) and their conversion to contractile, proliferative and fibrogenic cells responsible for the production of major extracellular matrix proteins (MEC) are the current focuses of investigation. However, the prospect of reversing hepatic fibrosis through the discovery of new antifibrotic therapies is even more attractive to researchers. This paper reviews these developments and ends with a view of the current state of human clinical trials.

Palavras-chave : Cirrhosis; stellate cells; fibrosis; matrix.