Revista Colombiana de Gastroenterologia
versão impressa ISSN 0120-9957
CASTANO-MOLINA, Eduardo; SANTACOLOMA, Mario; ARANGO, Lázaro e CAMARGO, Mauricio. Gastric cancer and detoxifying genes in a colombian population. Rev Col Gastroenterol [online]. 2010, vol.25, n.3, pp. 252-260. ISSN 0120-9957.
The objective was to establish whether there are associations between gastric cancer (GC) and unfavorable polymorphisms in GSTM1, GSTP1 and GSTT1 detoxifying genes. Simultaneously interactions of smoking habits, alcohol consumption and socioeconomic levels were investigated as possible risk factors in a Colombian population with a high incidence of GC. 87 patients affected by GC and 87 controls from the same population group in the Department of Caldas participated in the research. All patients were genotyped by PCR for GSTM1-null, GSTP1-val and GSTT1-null polymorphisms. Information about tobacco smoking, alcohol consumption and socioeconomic levels was collected. Results suggest that the GSTM1-nul genotype and GSTP1-val allele are significant risk factors as are low and medium socioeconomic levels. Significant interaction between tobacco smoking, low socioeconomic levels and GC risks were also detected. To conclude, there is significant interaction between environment and genes, particularly between the GSTT1-nulle genotype and GSTP1-val allele and low socioeconomic levels, tobacco smoking and the risk of GC development within this Colombian regions population.
Palavras-chave : Polymorphisms; GSTP1; GSTT1; GSTM1; tobacco smoking; socioeconomic level; gastric cancer.