SciELO - Scientific Electronic Library Online

 
vol.26 issue3Incidence of chronic kidney disease and risk factors for patients who underwent liver transplantation at Fundación Santa Fe University Hospital from 2004 to 2008 author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google

Share


Revista colombiana de Gastroenterología

Print version ISSN 0120-9957On-line version ISSN 2500-7440

Abstract

GOMEZ ZULETA, Martín; MELGAR BURBANO, Christian  and  OTERO REGINO, William. Comparison of sequential therapy for eradication of Helicobacter pylori with standard triple therapy. Rev Col Gastroenterol [online]. 2011, vol.26, n.3, pp.171-177. ISSN 0120-9957.

Introduction: Helicobacter pylori are involved in a large number of pathologies. Although first line therapies were developed to achieve high eradication rates, in recent years they have lost effectiveness. This has lead to the use of new therapies such as sequential therapy. This study compares eradication rates and collateral effects of sequential therapy (ST) and standard triple therapy (STT). Methods: This is a prospective randomized study of patients at El Tunal Hospital performed between November 2008 and September 2010. The study included patients with functional dyspepsia or peptic ulcers between 19 and 70 years of age who had undergone high digestive endoscopy for dyspeptic symptoms. Patients had not received H. Pylori eradication treatments for at least three months prior to endoscopies nor had they received antisecretory medications, bismuth or antibiotics during the previous month. Statistical calculations were done with SPSS. Results: At the end of the study 165 patients were included: 85 in the STT group (Group A) and 80 in the ST group (Group B). In group A 60 out of 80 patients (75 %) completed the treatment, but the infection was eradicated in only 51 patients for an 85% efficacy rate according to the protocol (95% CI: 73-92) and 63.75 % according to intention to treat (95% CI: 52-74). In Group B 70 out of 85 patients (82 %) completed the treatment, but the infection was eradicated in only 53 patients for a 75% efficacy rate according to the protocol (95% CI: 63-85) and 62% according to intention to treat (95% CI: 51-72). Conclusions: This study found low success rates with both STT and TS using generic medications in a population in Bogota. We consider it necessary to conduct similar studies using original medications and to conduct research about resistance to currently recommended antimicrobials in this population.

Keywords : Helicobacter pylori; eradication; sequential therapy; triple therapy.

        · abstract in Spanish     · text in English | Spanish     · English ( pdf ) | Spanish ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License