Abstract

SAAVEDRA GONZALEZ, Yesid Alberto; OVADIA CARDONA, Laura Margarita; MUNOZ MAYA, Octavio Germán  and  CORREA ARANGO, Gonzalo. Old and new paradigms for cirrhosis associated coagulation abnormalities. Rev Col Gastroenterol [online]. 2012, vol.27, n.2, pp.104-112. ISSN 0120-9957.

In liver disease one of the liver's functions related to blood coagulation, hemostasis, is disturbed. This manifests as hypercoagulability in some patients and as excessive bleeding in others. Objective: The objective of this study was to review current evidence about blood coagulation disorders in cirrhotic patients. Methods: We conducted a search using the following "MESH" terms: blood coagulation disorders, cirrhosis, hemostasis, hypercoagulability, bleeding and blood coagulation tests. From the results articles whose titles and abstracts best fit with the aim of this review were chosen. Results: From 146 articles obtained, 76 were selected and used to construct this article. Conclusion: Despite the diverse blood coagulation disorders present in cirrhotic patients, the hemostatic system accomplishes a new balance that currently used blood coagulation tests fail to show. This is the why these cannot be considered useful tools for predicting the risk of bleeding or thrombotic complications.

Keywords : Blood coagulation disorders; cirrhosis; hypercoagulability; bleeding; blood coagulation tests.

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