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Revista Colombiana de Gastroenterologia

Print version ISSN 0120-9957

Abstract

RIOS PATINO, David et al. Hepatitis B Infections in Individuals with Exposure Factors in Quibdo and Apartado, Colombia. Rev Col Gastroenterol [online]. 2015, vol.30, n.1, pp.11-18. ISSN 0120-9957.

Introduction: Colombia has a varied geographical pattern of prevalence of hepatitis B virus (HBV) infections with regions of high, moderate and low prevalences. Objective: The objective of this study was to identify cases of HBV infection and characterize viral genotypes in population with factors of exposure in the cities of Quibdo and Apartado, Colombia. Materials and Methods: The study population included 768 asymptomatic individuals with factors of exposure to HBV infections. An HBV surface antigen (HBsAg) rapid detection test was the first test used. Samples from individuals who tested positive were tested with ELISA to confirm the diagnosis and with PCR to detect the HBV genome. Viral genotypes were determined by sequencing and phylogenetic analysis. Results: Seventeen individuals (17/768, 2.2%) were diagnosed with HBV infections by both the Rapid Test and Elisa. Phylogenetic analyses allowed identification of genotypes F (F3 and Subgenotype F1a) and A in the samples. Conclusions: We report for the first time the presence of the F1a subgenotype in Colombia and confirme the presence of subgenotype F3 and genotype A

Keywords : Hepatitis B; Epidemiology; risk factors; genotypes.

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