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Revista Colombiana de Gastroenterologia

versión impresa ISSN 0120-9957

Resumen

BARRERA HERRERA, Luis Eduardo et al. Hepatoportal Sclerosis as a Cause of Portal Hypertension in a Colombian HIV patient without Cirrhosis. Rev Col Gastroenterol [online]. 2015, vol.30, n.1, pp.100-104. ISSN 0120-9957.

Background: Hepatoportal sclerosis manifests as non-cirrhotic portal hypertension. Its etiology appears to be related to alterations in the idiopathic micro-vasculature of the liver. Manifestations of hepatoportal sclerosis include upper gastrointestinal bleeding, pancytopenia, splenomegaly and non-cirrhotic portal hypertension. We present the first reported case of hepatoportal sclerosis in Colombia which occurred in an HIV positive patient. Methods: A 60-year-old male HIV patient positive was admitted to our institution because of ascites and upper digestive tract bleeding due to esophageal and fundal varices. Management required taking a liver biopsy. Results: A Tru-Cut biopsy needle was used to take a liver biopsy sample percutaneously. The biopsy revealed six to eight portal tracts with preserved architectural parenchyma, perivenular fibrosis and severe pericentral sinusoidal dilatation. Conclusions: Hepatoportal sclerosis is a cause of morbidity in HIV-positive patients and should be considered in each patient manifesting non-cirrhotic portal hypertension associated with upper gastrointestinal bleeding. However, further research is necessary to describe the relationship between the development of intrahepatic alterations (microthrombosis), HIV, and the use of anti-retroviral therapy, particularly the use of didanosine

Palabras clave : Tru-cut liver biopsy; hepatoportal sclerosis; non-cirrhotic portal hypertension; human immunodeficiency virus; anti-retroviral therapy.

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