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Revista Colombiana de Gastroenterologia

Print version ISSN 0120-9957

Abstract

LOPEZ PANQUEVA, Rocío del Pilar. Histopathological Evaluation of Liver Donors. Rev Col Gastroenterol [online]. 2015, vol.30, n.4, pp.485-495. ISSN 0120-9957.

The success of liver transplantation depends largely on the selection of the optimal donor and the best organ. In recent years significant work has been done to develop selection criteria and evidence-based organ assignments. Histopathological evaluation of liver biopsies plays an important role both in pretransplant evaluation of possibly marginal organs and in the diagnosis and treatment of patients who receive transplants. The use of intraoperative biopsies to evaluate organs found to be marginal in the pretransplant evaluation is opposed by some groups and supported by others. On the other hand, in contrast to the debate about the use of liver biopsies to evaluate donor organs, liver biopsies are still considered to be the “gold standard” for diagnosis of morphological changes such as acute rejection and chronic rejection that occur following transplantation. Nevertheless, the accuracy of biopsies has been questioned due to the variability and subjectivity of these evaluations which is caused primarily by the diagnostic difficulties posed by this disease and by the experience of the pathologist (1). The most important and frequent topics in this area will be discussed in this review. In addition, issues that can cause problems for diagnosing pathologies of the donor organ will be discussed. The article emphasizes pathological features and differential diagnosis. It is organized into three installments. This installment, the first, is about issues relevant aspects to biopsies of the donor organ

Keywords : Liver biopsy; frozen section; intraoperative consultation; donor liver; pretransplant evaluation; biopsy of donor liver; marginal donor.

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