Abstract

CARDONA-OSPINA, Jaime A; MEDINA-MORALES, Diego Alejandro; RODRIGUEZ-MORALES, Alfonso J  and  MACHADO-ALBA, Jorge E. Evidence Based Medicine Perspective on Long-Term Adverse Effects of Proton Pump Inhibitors. Rev Col Gastroenterol [online]. 2016, vol.31, n.4, pp.403-408. ISSN 0120-9957.

Proton pump inhibitors (PPIs) are the most effective gastric secretion suppressors and are among the most widely prescribed and widely available drugs in the United States of America. In some cases they are prescribed without justification. In recent years, concerns have arisen over reports of major adverse reactions related to the use of PPIs. However, the quality of the evidence has not been conclusive, and in some cases the magnitude of the risk has not been clinically significant. The objective of this review is to present the available evidence regarding the most important adverse events related to PPIs

Keywords : Proton pump inhibitors; adverse drug side effects; adverse drug reactions; evidence-based medicine; pharmacovigilance.

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