Abstract

RAMOS P, Christian et al. Chronic Liver Failure and Hemostasis. Rev Col Gastroenterol [online]. 2017, vol.32, n.4, pp.349-357. ISSN 0120-9957.  https://doi.org/10.22516/25007440.178.

Hepatic insufficiency is a pathology that conditions synthesis and metabolism of various biomolecules. Alterations of hemostasis is one of its first systemic consequences. Because of this and the size of the risks, it is not uncommon for clotting tests to be indispensable for formulating prognostic scales in patients with liver disease.

Knowledge about hemostasis has advanced in the last decade, and the classic cascade of activation of coagulation factors has been perfected until it has become the now-current cellular model that considers the valuable and indispensable participation of the endothelium and platelets. Thanks to this, it is possible to understand that the risk of bleeding in patients who have hepatic insufficiency is not only due to deficiencies in production of coagulation factors, and that for this reason administration of vitamin K is questionable. Even more relevant, is the fact that, thanks to this this knowledge, we can understand the sometimes contradictory and potentially life-threatening complication of thrombosis in these patients.

Keywords : Blood coagulation; liver failure; thrombosis; vitamin K.

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