Abstract

AFANADOR A, Carlos Humberto  and  MUNETON PENA, Carlos Mario. Epigenetics of Colorectal Cancer. Rev Col Gastroenterol [online]. 2018, vol.33, n.1, pp.32-40. ISSN 0120-9957.  https://doi.org/10.22516/25007440.229.

Colorectal cancer (CRC) has broad geographic distribution and affects millions of people throughout the world. It occurs sporadically in 80% of cases, but the rest have family histories. Epigenetic alterations such as DNA methylation and modification of histones and non-coding RNA are involved in the development of this disease. At present, these alterations have valuable potential as biomarkers for early detection of CRC and could be useful for diagnosis and determination of prognosis for individuals with CRC. The purpose of this review is to describe the main epigenetic mechanisms involved in colorectal cancer and the important roles they have in the development and progression of the disease.

Keywords : Colorectal cancer; epigenetics; DNA methylation; repair genes; tumor suppressor genes.

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