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Revista colombiana de Gastroenterología

Print version ISSN 0120-9957


ZULUAGA V, Laura Camila; RAMIREZ R, Natalia; MEJIA P, Lady Katherine  and  VERA CHAMORRO, José Fernando. Outcomes of treating infants with cow’s milk protein allergies with an extensively hydrolyzed serum-based formula. Rev Col Gastroenterol [online]. 2018, vol.33, n.2, pp.111-116. ISSN 0120-9957.


Cow’s milk protein allergies (CMPA) are the most frequent food allergies in the first year of life. Current evidence about responses to an extensively hydrolyzed serum based formula is insufficient.


This study’s objective was to determine clinical outcomes in infants with CMPA to an extensively hydrolyzed serum based formula (Nutrilón Pepti Junior®).


This is a retrospective case series study of infants 12 months old or younger diagnosed with CMPA in the outpatient clinic of a pediatric gastroenterology service between January 2011 and October 2015. Information including demographic data, digestive manifestations, time of onset of symptoms, anthropometry and clinical responses to formula was abstracted from a review of clinical histories. Patients’ nutritional statuses at first and one year follow-up consultations were compared using Student’s t-test.


Forty infants (42.5% males) whose average age was 3.3 ± 2.4 months were included. Their symptoms included vomiting/regurgitation, colic/irritability and bloody stools. Family and perinatal history related to the development of CMPA included bottle feeding in the first week of life (27 patients, 67.5%), mothers who were thirty years of age or older (33 patients, 82.5%), atopy in two family members (12 patients, 30 %) and cesarean deliveries (30 patients, 75%). Thirty-seven patients (92.5%) responded positively to an extensively hydrolyzed serum based formula while three patients (7.5%) did not respond and required a milk-free amino acid based formula. The first consultation z-score of P/E was -0.69 ± 1.03 while the first consultation z-score of P/T was -0.79 ± 1.00. These improved at the one year follow-up to (p <0.05) P/E: -0.27 ± 0.98 and P/T: -0.14 ± 0.98, respectively.


Nutritional recovery and tolerance to cow’s milk was found in a high percentage of infants with CMPA who received an extensively hydrolyzed serum based formula.

Keywords : Food allergy; cow’s milk protein; infant; nutrition.

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