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Revista colombiana de Gastroenterología

Print version ISSN 0120-9957


DIAZ-RAMIREZ, Gabriel Sebastián et al. Experience of a liver transplant center in Medellín, Colombia with liver transplantation for autoimmune hepatitis and characteristics associated with post-transplant recurrence. Rev Col Gastroenterol [online]. 2018, vol.33, n.3, pp.242-248. ISSN 0120-9957.


The recurrence of post-transplant autoimmune hepatitis implies risk of cirrhosis and graft loss. Risk factors have been proposed for recurrence, of which few data are known in Latin American patients.


To describe the characteristics of patients with liver transplantation for autoimmune hepatitis and to evaluate those associated with their recurrence during post-transplant.


Historical cohort included patients with autoimmune hepatitis diagnosed after the age of 16 years and who were taken to liver transplant in a university hospital in Medellin, Colombia between January 2010 and September 2017. Collection of information from the registers of clinical history.


25 patients were included. Recurrence was diagnosed in 24%. Median follow-up was 59.5 months and recurrence 32.5 months (range 11-123 months). 100% of the recurrence group were women and none of these were transplanted due to acute liver failure. There were no differences in the pre-transplant and treatment characteristics, although a higher biochemical and histological inflammatory activity was found pre-transplant in the recurrence group. Of the group with recurrence, 100% received long-term glucocorticoids and 33.3% had graft loss related to recurrence requiring retransplantation (p = 0.008).


The recurrence of autoimmune hepatitis after liver transplantation in our patients is similar to that reported worldwide, is a cause of graft dysfunction to be taken into account especially after the first year post-transplant, it predominates in women. 33.3% of patients require hepatic retransplantation due to graft dysfunction.

Keywords : Autoimmune hepatitis; liver transplant; Latin America; Colombia.

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