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Revista Colombiana de Gastroenterologia

Print version ISSN 0120-9957

Abstract

LEDEZMA-MORALES, Mónica  and  AMARILES, Pedro. Treatment of chronic hepatitis C in elderly patients with chronic kidney disease: a structured review. Rev Col Gastroenterol [online]. 2018, vol.33, n.3, pp.269-284. ISSN 0120-9957.  http://dx.doi.org/10.22516/25007440.189.

Hepatitis C (HC) is a public health problem worldwide and has especially high prevalence in patients over 50 years of age. This population is more prone to suffer from chronic kidney disease (CKD) due to HC infections as well as to age and multiple comorbidities. Those with CKD stages 4 or 5 constitute a population of greater pharmacotherapeutic complexity due to pharmacological variability and limited information on the safety and efficacy of the new antivirals for this group of patients.

Objective:

This article systematizes information about medications and proper dosages for treating chronic HC and is based on studies and reports that include elderly patients with CKD.

Materials and method:

This is a structured review of studies carried out in humans with access to full text published between 01/08/2012 and 01/08/2017 in English or Spanish found in PubMed/Medline using the terms: “Hepatitis C”, “Aged”, and “Renal Insufficiency”.

Results:

Eighty-three articles were identified, fourteen of which were selected. In addition, four manuscripts referenced in those publications were included. A table with antiviral dosing information for treatment of HC in elderly patients with CKD was structured.

Discussion:

We present information on adjustment of dosages of antiviral drugs used for chronic HC in elderly patients and CKD. This could favor prescription and monitoring thereby contributing to the effectiveness and safety of these drugs in this population.

Keywords : Hepatitis C; elderly; kidney diseases; antivirals.

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